scholarly journals Heat shock proteins: the fountainhead of innate and adaptive immune responses

2000 ◽  
Vol 5 (5) ◽  
pp. 443 ◽  
Author(s):  
Sreyashi Basu ◽  
Pramod K. Srivastava
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Shock Proteins

Heat Shock Proteins and Scavenger Receptors: Role in Adaptive Immune Responses

2005 ◽  
Vol 34 (3) ◽  
pp. 325-342 ◽  
Author(s):  
John G. Facciponte ◽  
Ian J. MacDonald ◽  
Xiang-Yang Wang ◽  
Hyung Kim ◽  
Masoud H. Manjili ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Scavenger Receptors ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Shock Proteins

scholarly journals Immune responses of leishmaniasis patients to heat shock proteins of Leishmania species and humans.

1995 ◽  
Vol 63 (10) ◽  
pp. 4105-4114 ◽  
Author(s):  
Y A Skeiky ◽  
D R Benson ◽  
J A Guderian ◽  
J A Whittle ◽  
O Bacelar ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Leishmania Species ◽  
Shock Proteins

scholarly journals A Mage3/Heat Shock Protein70 DNA vaccine induces both innate and adaptive immune responses for the antitumor activity

Vaccine ◽  
2009 ◽  
Vol 28 (2) ◽  
pp. 561-570 ◽  
Author(s):  
Lifeng Wang ◽  
Lisa Rollins ◽  
Qinlong Gu ◽  
Si-Yi Chen ◽  
Xue F. Huang
Keyword(s):  
Heat Shock ◽  
Antitumor Activity ◽  
Immune Responses ◽  
Dna Vaccine ◽  
Adaptive Immune Responses ◽  
Adaptive Immune

scholarly journals Myeloma cell line–derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma

Blood ◽  
2009 ◽  
Vol 114 (18) ◽  
pp. 3880-3889 ◽  
Author(s):  
Jianfei Qian ◽  
Sungyoul Hong ◽  
Siqing Wang ◽  
Liang Zhang ◽  
Luhong Sun ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Immune Responses ◽  
Cell Line ◽  
Cell Lines ◽  
Tumor Antigens ◽  
Myeloma Cell ◽  
Myeloma Cell Line ◽  
Custom Made ◽  
Shock Proteins

Abstract Tumor cell–derived heat shock proteins are used as vaccines for immunotherapy of cancer patients. However, current approaches require the generation of custom-made products and are clinically ineffective. To improve the applicability of heat shock protein–based immunotherapy in cancers and to enhance clinical efficacy, we explored combinational treatments in a myeloma setting using pooled heterogeneous or allogeneic myeloma cell line–derived glycoprotein 96 (gp96) as universal vaccines, and clearly demonstrated that pooled but not single gp96 from heterogeneous or allogeneic myeloma cell lines was as effective as autologous gp96 in protecting mice from tumor challenge and rechallenge and in treating established myeloma. We showed that interferon γ and CD4+ and CD8+ T cells were required for gp96-induced antimyeloma responses and that pooled gp96 induced broader immune responses that protected mice from developing different myeloma. Furthermore, pooled gp96 plus CpG in combination with anti-B7H1 or anti–interleukin-10 monoclonal antibodies were effective in treating mice with large tumor burdens. Thus, this study strongly suggests that pooled gp96 vaccines from myeloma cell lines can replace gp96 vaccines from autologous tumors for immunotherapy and induce immune responses against broader tumor antigens that may protect against tumor recurrence and development of unrelated tumors in vaccinated myeloma patients.

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